MAGL modulators: structure-guided optimisation and characterisation

Author(s):
Huizenga, M.C.W. (0000-0001-8313-0019)
Published
2024
Publication type
Doctoral Thesis

Abstract

The aim of the research described in this thesis was to use structure-based design to optimise multiple properties of aryl sulfoxide monoacylglycerol lipase inhibitors as anti-inflammatory analgesics.

Medicinal chemistryEndocannabinoid systemStructure-guided drug designPROTACs
Defense date
2024-09-10
Language
English
Supervisor(s)
Stelt, M. van der
Advisor(s)
Janssen, A.P.A.; Berg, R.J.B.H.N. van den
Committee member(s)
Kasteren, S.I. van; Ubbink, M.; Perrakis, A.; Heitman, L.H.; Nazaré, M.; Dekker, F.J.
Qualification
Ph.D.
Degree granting institution
Leiden Institute of Chemistry (LIC), Faculty of Science, Leiden University, Leiden
hdl
1887/4082969
ISBN(s)
9789465061665

Funding

Sponsorship
Oncode Institute