Non‐linear blood–brain barrier transport and dosing strategies influence receptor occupancy ratios of morphine and its metabolites in pain matrix

Author(s):
Budda, D.; Gülave, B.; Hasselt, J.G.C. van (0000-0002-1664-7314); Lange, E.C.M. de (0000-0001-8303-1117)
Published
2024
Publication type
Article / Letter to editor
Competitive receptor binding kinetics, Morphine, Morphine-3-glucuronide, Morphine-6-glucoronide, Pain matrix, μ-opioid receptor
Date issued
2024-04-25
Language
English
Publisher
Wiley
Is part of
British Journal of Pharmacology (2024), Vol. 181, no. 20, p. 3856-3868
hdl
1887/4082375
doi
10.1111/bph.16394

Funding

Sponsorship
Horizon 2020(H2020)
Grant number
848068