The Dutch Retinopathy of Prematurity Study: NEDROP 2

Trzcionkowska, K. (2024)

Doctoral Thesis

Retinopathy of prematurity (ROP) is the most important cause of vision loss premature infants. With a continuous growth in this vulnerable population, the number of newborns at risk for severe, sight threatening ROP increases. In this thesis the results of the national Dutch inventory on risk factors, screening, treatment and sequelae of ROP are presented. The principal aims of the study were to determine characteristics of newborns who are at highest risk to develop severe ROP to assess quality of screening and treatment and to evaluate the national ROP guideline. Following these studies together with extensive cost-effectiveness analyses, the current Dutch ROP screening and treatment guideline was adapted and implemented in November 2023. The NEDROP 2 allowed for more stringent screening inclusion criteria, lowering the number of infants that need to undergo burdensome screening under the precondition that no severe ROP would be missed. Annually, this will lower the screening costs by nearly 60,000 euros.

• Retinopathy of prematurity
• Ophthalmology
• Neonatology
• Retina
• Risk factors
• Screening
• Laser
• Vitrectomy
• Sequelae

• All authors: Trzcionkowska, K.
• Supervisor: Schalij-Delfos, N.E.
• Co-supervisor: Termote, J.U.M.
• Committee: Luyten, G.P.M.; Lopriore, E.; Boon, C.J.F.; Reiss, I.; Arends-Tjam, A.M.
• Qualification: Doctor (dr.)
• Awarding Institution: Faculty of Medicine, Leiden University Medical Center (LUMC), Leiden University
• Date: 2024-06-27
• ISBN (print): 9789464699722
• Sponsorship: ODAS stichting