Understanding ventricular tachycardia : towards individualized substrate-based therapy

Author(s):
Piers, S.R.D.
Published
2016
Publication type
Doctoral Thesis

Abstract

Patients with structural heart disease - e.g. after myocardial infarction or due to a cardiomyopathy - are at increased risk for sudden cardiac death because of arrhythmia. The department of Cardiology at the Leiden University Medical Center has a strong interest for the underlying substrate and mechanisms of ventricular arrhythmias. Since 2011, research fellow Sebastiaan Piers and his supervisor prof. dr. Katja Zeppenfeld have performed innovative studies, combining advanced electrophysiological data with detailed imaging data derived from CT and MRI. These studies have led to important insights into the substrate and mechanisms of ventricular arrhythmia in patients after myocardial infarction or with a cardiomyopathy. An improved understanding may be the most important prerequisite for the development of effective, individualized and substrate-based therapies for ventricular arrhythmias in the future. Sebastiaan Piers will defend his thesis "Understanding Ventricular Tachycardia: Towards Individualized Substrate-based Therapy" on Thursday January 28th 2016.

MRICTNonischemic cardiomyopathyMyocardial infarctionCatheter ablationVentricular tachycardia
Defense date
2016-01-28
Language
English
Supervisor(s)
Zeppenfeld, K.; Schalij, M.J.
Qualification
Ph.D.
Degree granting institution
Departments of Cardiology and Electrofysiology, Faculty of Medicine, Leiden University Medical Center (LUMC), Leiden University, Leiden
hdl
1887/37413
ISBN(s)
9789461697912

Funding

Sponsorship
The printing of this thesis was financially supported by St. Jude Medical, Biotronik, Bayer HealthCare, Sanofi Aventis, Chipsoft, Medis Medical Imaging and Toshiba Medical Systems. Het verschijnen van dit proefschrift werd mede mogelijk gemaakt door de steun van de Nederlandse Hartstichting en de Stichting Wetenschap en Onderzoek Interne Geneeskunde Onze Lieve Vrouwe Gasthuis.