Contextual glucocorticoid signaling in-vivo: a molecular perspective

Buurstede, J.C. (2023)

Doctoral Thesis

What we collectively call “stress” is how we experience our body’s reaction to a stressor. This response is aimed to deal with the current stressor and to prepare for recurrences in the future. The stress response is for an important part dependent on glucocorticoid hormones. By and large, the acute response to glucocorticoids is beneficial, but chronic exposure often becomes maladaptive. To improve prevention and treatment of disorders we can develop due to stress, it is important to better understand the effects and working mechanisms of glucocorticoids. While we already possess extensive knowledge regarding glucocorticoids and glucocorticoid receptor signaling, we introduced and studied five “aspects of context”, which we felt address important current misconceptions or gaps of knowledge. Corticosterone was at the center of all the studies we performed, yet the eventual outcome of glucocorticoid receptor activation differed extensively in all experiments. Thus, the context in which corticosterone exerts its effects matters, and it is to researcher to be aware of this when designing new studies and interpreting available data. Whilst our research merely addressed some specific processes, the lessons learned from these experiments can be applied much broader to the biology of glucocorticoid signaling and other nuclear family members.

• Hormones
• Corticosterone
• Molecular biology
• Transcription
• Stress
• Memory

• All authors: Buurstede, J.C.
• Supervisor: Meijer, O.C.; Joëls, M.
• Co-supervisor: Krugers, H.J.
• Committee: Willems van Dijk, J.A.P.; Clemens-Daxinger, L.; Lucassen, P.J.; Schaaf, M.J.M.
• Qualification: Doctor (dr.)
• Awarding Institution: Faculty of Medicine, Leiden University Medical Center (LUMC), Leiden University
• Date: 2023-12-07
• ISBN (print): 9789464834239
• Sponsorship: Corcept Therapeutics; BGI Genomics