Genomic driven treatment and drug rediscovery in patients with advanced cancer

Abstract

This thesis focuses on precision oncology, discussing the findings of the Drug Rediscovery Protocol (DRUP) and examining the diverse patient groups treated in this study. In DRUP, an innovative Dutch study, patients with advanced-stage cancer, for whom all available treatment options have been exhausted, are treated with approved targeted therapies, applied beyond there registered indications. The primary goal of DRUP is to improve outcomes for individual patients by implementing a personalized treatment strategy: the right therapy for the right patient at the right time.