Exploring the mechanisms of metastatic onset for novel treatment strategies

Author(s):
Zhao, G.
Published
2023
Publication type
Doctoral Thesis

Abstract

This thesis represents a comprehensive investigation into the control of cancer stemness and metastatic initiation using a combination of advanced zebrafish xenograft models and in vitro assays. The discoveries made and the evaluation of drug efficacy provide valuable insights for the development of novel therapeutic approaches in the fight against metastatic cancer.

Zebrafish xenograftPDX-derived organoidsCancer, MechanotransductionMetastasisAMPK - mTOR crosstalkPhotoactivated, Ruthenium-peptide prodrugLipid-nanoparticlesRNA therapeutics
Defense date
2023-12-05
Language
English
Supervisor(s)
Snaar-Jagalski, B.E.; Kruithof-deJulio, M.
Advisor(s)
Chen, L.
Committee member(s)
Meijer, A.H.; Spaink, H.P.; Dijke, P. ten; Kros, A.; Groenewoud, A.
Qualification
Ph.D.
Degree granting institution
Institute of Biology Leiden (IBL), Faculty of Science, Leiden University, Leiden
hdl
1887/3665669
ISBN(s)
9789464732900

Funding

Sponsorship
China Scholarship Council (CSC); Leiden University Scholarship