Discovery and characterization of new glucosylated metabolites: pathophysiological consequences

Author(s):
Meijer, H.N.J.
Published
2023
Publication type
Doctoral Thesis

Abstract

Within this thesis the central stage is taken by the discovery and investigation of transglycosylation of sterols. First, investigation focuses on the development of a method to accurately detect and quantify glucosylated metabolites in biological materials. Next, the studies concentrate on the formation and occurrence of specific glucosylated metabolites, in particular glucosyl-desmosterol (GlcDesm), glucosyl-7-dehydrocholesterol (Glc7DHC) and glucosylated vitamin D3 (GlcD3).

TransglucosylationGlucosylated metabolitesGlucosyl-desmosterolGlucosyl-7-dehydrocholesterolGlucosylated vitamin D3GlucocerebrosidaseGBA1 cerezymeGBA2GBA3Gaucher disease
Defense date
2023-11-02
Language
English
Supervisor(s)
Aerts, J.M.F.G.
Advisor(s)
Boot, R.G.
Committee member(s)
Overkleeft, H.S.; Stelt, M. van der; Dame, R.T.; Hankemeier, T.; Vries, C.J.M. de; Houtkoper, R.H.L.
Qualification
Ph.D.
Degree granting institution
Leiden Institute of Chemistry (LIC), Faculty of Science, Leiden University, Leiden
hdl
1887/3655909
ISBN(s)
9789464732566