Development of nanoparticulate adjuvants based on aluminium salts

Author(s):
Vrieling, H.
Published
2023
Publication type
Doctoral Thesis

Abstract

The aim of this thesis was to develop aluminium salt-based nanoparticles that may ultimately be used as adjuvant in human vaccines. Compared to traditional aluminium salt-based adjuvants, nanoparticles may improve vaccine efficacy and reduce encountered side effects. Nanoparticles were synthesised and their physicochemical properties were investigated. Their immunostimulating properties were investigated in vitro and in vivo and compared to traditional aluminium salt-based adjuvants.

AdjuvantNanoparticulate adjuvantAluminum saltsAluminum hydroxideAluminum phosphate
Defense date
2023-09-21
Language
English
Supervisor(s)
Kersten, G.F.A.; Jiskoot, W.
Advisor(s)
Metz, B.
Committee member(s)
Irth, H.; Bouwstra, J.A.; Meijer, A.H.; Huckriede, A.L.W.; Reed, S.G.
Qualification
Ph.D.
Degree granting institution
Leiden Academic Centre for Drug Research (LACDR), Faculty of Science, Leiden University, Leiden
hdl
1887/3641811
ISBN(s)
9789464732047