IBD-associated dysplastic lesions show more chromosomal instability than sporadic adenomas

Author(s):
Wanders, L.K.; Cordes, M. (0000-0001-5643-1676); Voorham, Q.; Sie, D.; Vries, S.D. de; d'Haens, G.R.A.M.; Boer, N.K.H. de; Ylstra, B.; Grieken, N.C.T. van; Meijer, G.A.; Dekker, E.; Carvalho, B.
Published
2020
Publication type
Article / Letter to editor

Abstract

Inflammatory bowel disease (IBD) patients are at increased risk of developing colorectal cancer. However, histologically, it is challenging to distinguish between IBD-associated dysplasia from sporadic adenomas. We have molecularly characterized these precursor lesions and show that IBD-associated dysplasia lesions are genomically much more unstable.

Date issued
2020-06-01
Language
English
Publisher
Oxford University Press ({OUP})
Is part of
Inflammatory Bowel Diseases (2020), Vol. 26, no. 2, p. 167-180
hdl
1887/3627354
doi
10.1093/ibd/izz171
URL
https://academic.oup.com/ibdjournal/article/26/2/167/5542808