Integrated and dual-responsive lipopeptide nanovector with parallel effect to tumor and micro-environment regulation by efficient gene and drug co-delivery

Author(s):
Chen, X.B.; Yang, H.; Song, X.; Liang, H.; Wei, Y.; Lu, J.; Barz, M. (0000-0002-1749-9034); Jin, R.R.; Nie, Y.
Published
2023
Publication type
Article / Letter to editor

Abstract

The integrated lipopeptide (RVA)/gene complexes are fabricated with bi-directional regulation on tumor cells and micro-environment. After self-assembling and target coating modification, the poly(gamma-glutamic acid) (gamma-PGA)/RVA nano-vectors can sequentially respond to pH & redox stimuli, and guarantee efficient therapeutic gene delivery and control release of all -trans retinoic acid. The design provides a facile but promising strategy to treat refractory cancers.(c) 2023 Published by Elsevier B.V. on behalf of Chinese Chemical Society and Institute of Materia Medica, Chinese Academy of Medical Sciences.

Date issued
2023-03-24
Language
English
Publisher
ELSEVIER SCIENCE INC
Is part of
Chinese Chemical Letters (2023), No. 5, 107753
hdl
1887/3620364
doi
10.1016/j.cclet.2022.107753