Surveillance for familial and hereditary pancreatic ductal adenocarcinoma

Ibrahim, I.S. (2023)

Doctoral Thesis

Pancreatic ductal adenocarcinoma is one of the most lethal forms of cancer. This book describes the outcome of long-term surveillance for p16-Leiden/CDKN2A mutation carriers. Further evaluating the role of precursor lesions, including IPMN and PanIN in the development of PDAC. It is also common knowledge that hereditary cancer is associated with the development of multiple tumors due to the fact that all body cells carry the inherited mutation. Therefore the third aid was to evaluate the risk of multiple PDAC in carriers of a p16-Leiden founder mutation. The fourth aim was to evaluate cost-effectiveness of surveillance. During our surveillance study, the program unexpectedly detected also other types of cancer than PDAC including benign lesions (incidentaloma). The fifth aim was to evaluate what type of cancers and benging lesions were detected and whether surveillance and early detection offered any benefit. The final aim was to describe the dilemmas in the management of screen-detected lesions that we experienced during our surveillance program.

• Pancreatic Ductal Adenocarcinoma
• CDKN2A
• p16-Leiden mutation
• Surveillance
• High risk individuals
• PanIN
• IPMN

• All authors: Ibrahim, I.S.
• Supervisor: Vasen, H.F.A.; Morreau, J.
• Co-supervisor: Wasser, M.N.J.M.
• Committee: Hooft, J.E. van; Bartsch, D.K.A.; Bruno, M.J.; Vos tot Nederveen, W.H. de
• Qualification: Doctor (dr.)
• Awarding Institution: Faculty of Medicine, Leiden University Medical Center (LUMC), Leiden University
• Date: 2023-06-01
• ISBN (print): 9789464693256
• Sponsorship: Universiteit Leiden; HIX; ABN Amro