The CuA site of cytochrome c oxidase

Author(s):
Dennison, C.; Canters, G.W. (0000-0002-8496-2332)
Published
2010
Publication type
Article / Letter to editor

Abstract

The recent exciting developments concerning the structure and function of the Cu-A site in cytochrome c oxidase (COX) and nitrous oxide reductase are reviewed. The XRD structures of a mitochondrial and a bacterial COX have been reported in 1995, In COX, the Cu-A centre is located in subunit II and is involved in electron transfer from a cytochrome c donor to the oxygen binding centre of the protein. The structural studies on the enzyme have revealed the coordination geometries of the many metal centres of COX, including the Cu-A site. A combination of spectroscopic and mutagenesis studies on the Cu-A centre led to the correct prediction of the structure of this unique copper centre. The construction of a Cu-A site in type 1 blue copper proteins is briefly discussed.

Date issued
2010-09-02
Language
English
Publisher
ELSEVIER SCIENCE BV
Is part of
Recueil des Travaux Chimiques des Pays-Bas = Journal of the Royal Netherlands Chemical Society (2010), Vol. 115, no. 7-8, p. 345-351
hdl
1887/3618610
doi
10.1002/recl.19961150702