Migraine as a cardiovascular risk factor for women

Author(s):
Linstra, K.M.
Published
2023
Publication type
Doctoral Thesis

Abstract

In this thesis, the role of migraine as a cardiovascular risk factor is investigated in different populations with a varying medical history, including stroke and polycystic ovary syndrome (PCOS)⁠. We focused primarily on women and sex-specific features, exploring both conventional and novel measures for vascular health⁠. This thesis was written in the context of the CREW consortium⁠. The aim of the CREW consortium, a cooperation of major medical centers in the Netherlands and commissioned by the Dutch Heart Institute, was to study female-specific cardiovascular pathophysiology⁠. The CREW-MIST (Cardiovascular Riskprofile in Women – MIcrovascular STatus) project, which was part of this consortium, focused on migraine in relation to stroke in women⁠. Female-specific factors such as sex hormone- and pregnancy-related disorders were included in our studies and we explored microvascular health through heart- and brain imaging and functional measurements of the vasculature⁠.

MigraineSex hormonesWomen's healthCardiovascular riskIschemic strokeEndothelial dysfunctionPolycystic ovary syndromePreeclampsia
Defense date
2023-05-16
Language
English
Supervisor(s)
Wermer, M.J.H.; Maassen van den Brink, A.; Terwindt, G.M.
Committee member(s)
Cannegieter, S.C.; Kruit, M.C.; Boersma, H.; Roeters van Lennep, J.E.
Qualification
Ph.D.
Degree granting institution
Faculty of Medicine, Leiden University Medical Center (LUMC), Leiden University, Leiden
hdl
1887/3618277
ISBN(s)
9789464830729

Funding

Sponsorship
de Nederlandse Hartstichting