Lipidomics analysis in drug discovery and development

Author(s):
Kostidis, S.; Sanchez-Lopez, E.; Giera, M.
Published
2022
Publication type
Article / Letter to editor

Abstract

Despite being a relatively new addition to the Omics' land-scape, lipidomics is increasingly being recognized as an important tool for the identification of druggable targets and biochemical markers. In this review we present recent ad-vances of lipid analysis in drug discovery and development. We cover current state of the art technologies which are constantly evolving to meet demands in terms of sensitivity and selectivity. A careful selection of important examples is then provided, illustrating the versatility of lipidomics analysis in the drug discovery and development process. Integration of lipi-domics with other omics', stem-cell technologies, and meta-bolic flux analysis will open new avenues for deciphering pathophysiological mechanisms and the discovery of novel targets and biomarkers.

LipidomicsMass spectrometryBiomarkerDrug developmentDrug discovery
Date issued
2022-12-29
Language
English
Publisher
ELSEVIER SCI LTD
Is part of
Current Opinion in Chemical Biology
hdl
1887/3590799
doi
10.1016/j.cbpa.2022.102256
URL
https://www.sciencedirect.com/science/article/pii/S1367593122001417?via%3Dihub