What's in a face? the early developmental impact of Sex Chromosome Trisomies (XXX, XXY, XYY) on social cognition

Author(s):
Bouw, J.C. (0000-0002-4858-6085)
Published
2023
Publication type
Doctoral Thesis

Abstract

This thesis describes the impact of Sex Chromosome Trisomies (SCT; XXX, XXY, XYY) on early social cognition. Individuals with SCT have an increased vulnerability for developing challenges on the social domain, given the convergent impact of the X and Y chromosome on brain networks that underly social adaptive development. We found that already from a very early age on, SCT can be associated with increased risk for vulnerabilities in social interactions, and with increased levels of social impairments associated with ASD. These findings suggest that SCT impact the maturation of the social brain already from an early age, and stresses the importance of early routine monitoring and (preventive) support of early social development in young children with SCT.

Sex Chromosome TrisomiesSocial cognitionnAutism Spectrum DisorderSocial communication
Defense date
2023-03-15
Language
English
Supervisor(s)
Rijn, S. van; Swaab, H.
Committee member(s)
Alink, L.R.A.; Rieffe, C.J.; Egger, J.I.M.; Jansen, A.C.; Biro, S.; Staal, W.G.
Qualification
Ph.D.
Degree granting institution
Leiden Institute of Education and Child Studies, Faculty of Social and Behavioural Sciences, Leiden University, Leiden
hdl
1887/3589855

Funding

Sponsorship
NWO