Effects of muscle damage on P-31-MRS indices of energetic status and sarcolemma integrity in young mdx mice

Abstract

The article of Lopez et al describes the use of a multi-parametric MR approach to study muscle T-2 relaxation times and P-31-MRS indices of energetics and sarcolemma integrity in a mouse model of DMD, the mdx mouse. Muscular dystrophies have a multi-factorial disease cascade, and there are several MR methods used to assess these. Aspects that reflect disease progression are outlined on the left, while features that are more related to disease activity are outlined on the right.