Neurovascular imaging markers of brain aging

Author(s):
Sigurdsson, S.
Published
2023
Publication type
Doctoral Thesis

Abstract

The general aim of this thesis was to study the frequency, causes and consequences of pathologic brain aging specifically focusing on sub-clinical and clinical MRI manifestations of vascular (small vessel disease) and neurodegenerative (brain atrophy) disease.

A second aim was to improve the accuracy of the tools to quantify brain tissue so to better reflect the imaging characteristics of older people. All data presented in this thesis are from the AGES-Reykjavik Study including 5764 elderly men and women. The data is based on cross-sectional and longitudinal assessments of the brain with MRI measures.

MRIAgingDementiaBrainPopulation Bases Study
Defense date
2023-02-21
Language
English
Supervisor(s)
Buchem, M.A. van
Advisor(s)
Launer, L.J.
Committee member(s)
Osch, M.J.P. van; Cannegieter, S.C.; Blauw, G.J.; Vernooij, M.; Gudnason, V.
Qualification
Ph.D.
Degree granting institution
Faculty of Medicine, Leiden University Medical Center (LUMC), Leiden University, Leiden
hdl
1887/3564753
ISBN(s)
9789463618021