Follow your label: simultanous 4D angiography and perfusion imaging by arterial spin labeling MRI

Author(s):
Plas, M.C.E. van der
Published
2023
Publication type
Doctoral Thesis

Abstract

In this thesis, multiple approaches have been investigated for the simultaneous acquisition of 4D angiography and perfusion images using arterial spin labeling (ASL) MRI. Time-encoded pseudo-continuous (ASL) preparation was combined with multiple different readout modules, such as Look-Locker, Simultaneous multi-slice acquisition or a golden angle based non-Cartesian k-space trajectory to obtain high temporal resolution multi-time point data. These datasets were then used to improve the quantification of ASL signal and to obtain cerebral blood flow, arterial transit time and arterial blood volume maps. These quantitative maps hold the potential to provide important information in for example patients with stroke or Alzheimer’s disease. In addition, one of the assumptions within the two-component kinetic model to obtain these quantitative maps was investigated to study the separation of the macrovascular and perfusion component of the ASL signal.

Magnetic Resonance ImagingArterial Spin LabelingPerfusionAngiographyNeuroCerebral blood flowArterial blood volumeGolden angle radial/spiralTime-encoded pCASL
Defense date
2023-02-23
Language
English
Supervisor(s)
Osch, M.J.P. van
Advisor(s)
Webb, A.G.
Committee member(s)
Heide, U.A. van der; Smits, M.; Poser, B.; Achten, E.
Qualification
Ph.D.
Degree granting institution
Faculty of Medicine, Leiden University Medical Center (LUMC), Leiden University, Leiden
hdl
1887/3564723