Design, synthesis, and evaluation of antigenic peptide conjugates containing Toll-like receptor agonists

Author(s):
Ende, T.C. van den (0000-0002-6336-259X)
Published
2023
Publication type
Doctoral Thesis

Abstract

This thesis describes the design, synthesis, and immunological evaluation of varying (neo)antigenic peptide conjugates containing either a TLR2 or a TLR7 agonist. Chapter 2 discusses the synthesis of a library of UPam functionalized (neo)antigenic peptides. Chapter 3 discusses the optimization of UPam and investigates the current paradigms surrounding UPam. Chapter 4 presents a new simplified agonist for TLR2, namely mini-UPam, which is then conjugated to some neoantigenic peptides and evaluated on its immunological properties. Chapter 5 discusses the design and synthesis of TLR2 and TLR7 dual functionalized antigenic peptides.

Toll-like receptorTLR2TLR7Neoantigenic peptideSynthetic peptidePeptide conjugatePeptide synthesis
Defense date
2023-02-21
Language
English
Supervisor(s)
Ossendorp, F.A.; Marel, G.A. van der; Flippov, D.V.
Committee member(s)
Ubbink, M.; Codee, J.D.C.; Overkleeft, H.S.; Kasteren, S.I. van; Geluk, A.; Buschow, S.I.
Qualification
Ph.D.
Degree granting institution
Leiden Institute of Chemistry (LIC), Faculty of Science, Leiden University, Leiden
hdl
1887/3564186
ISBN(s)
9789464589214