Durability of immune responses after boosting in Ad26.COV2.S-primed healthcare workers

Author(s):
Sablerolles, R.S.G.; Rietdijk, W.J.R.; Goorhuis, A.; Postma, D.F.; Visser, L.G. (0000-0002-3600-9782); Schmitz, K.S.; Geers, D.; Bogers, S.; Haren, E. van; Koopmans, M.P.G.; Dalm, V.A.S.H.; Kootstra, N.A.; Huckriede, A.L.W.; Akkerman, R.; Beukema, M.; Lafeber, M.; Baarle, D. van; Vries, R.D. de; Kuy, P.H.M. van der; GeurtsvanKessel, C.H.; SWITCH Res Grp
Published
2022
Publication type
Article / Letter to editor

Abstract

The emergence of SARS-CoV-2 variants raised questions regarding the durability of immune responses after homologous or heterologous boosters after Ad26.COV2.S-priming. We found that SARS-CoV-2-specific binding antibodies, neutralizing antibodies, and T cells are detectable 5 months after boosting, although waning of antibodies and limited cross-reactivity with Omicron BA.1 was observed.

SARS-CoV-2Ad26COV2Swaning immunity
Date issued
2022-06-20
Language
English
Publisher
OXFORD UNIV PRESS INC
Is part of
Clinical Infectious Diseases (2022), Vol. 76, no. 3, p. e533-e536
hdl
1887/3514665
doi
10.1093/cid/ciac495