MRI for planning and characterization of uveal melanoma patients treated with proton beam therapy

Author(s):
Jaarsma-Coes, M.G.
Published
2023
Publication type
Doctoral Thesis

Abstract

In this thesis I investigate new ways to use MRI (magnetic resonance imaging) for the diagnosis, treatment and follow-up of uveal melanoma (UM) patients, mainly in relation to the planning of proton beam therapy.

Proton beam therapy is performed while sitting whereas MRI scans are scanned in prone position. In chapter 2 I have shown that the shape of the eye and tumor are not affected by the change in position. During treatment planning the tumor shape needs to be determined. This can be done by drawing the tumor on MRI. In chapter 3 I have shown that the variance between segmentations performed by different doctors are on average smaller then 0.4mm. As MRI based planning is not yet available for UM patients we have developed an MRI protocol to support the current model based treatment planning software with MRI based measurements. In chapter 4 I compare these MRI based measurements with conventional measurements and show that MRI measurements are comparable and sometimes even better. A common side effect of UM is retinal detachment. This is sometimes treated with silicon oil. Unfortunately ultrasound imaging is not possible in these patients. In chapter 5 I describe and evaluate a MRI protocol to imaging these tumors with MRI. Finally, MRI can also provide information about tissue and functional characteristics. In chapter 6 I present a method to overcome eye specific challenges in the quantitative analysis of perfusion weighted MRI.

Magnetic resonance imagingOcular oncologyProton beam therapyUltrasoundUveal melanoma
Defense date
2023-02-02
Language
English
Supervisor(s)
Webb, A.G.; Luyten, G.P.M.
Advisor(s)
Beenakker, J.W.M.
Committee member(s)
Osch, M.P.J. van; Graaf, P. de; Hoogeman, M.S.; Jager, M.J.; Joussen, A.M.
Qualification
Ph.D.
Degree granting institution
Faculty of Medicine, Leiden University Medical Center (LUMC), Leiden University, Leiden
hdl
1887/3514571
ISBN(s)
9789463617987

Funding

Sponsorship
14654, which is financed by the Dutch Research Council (NWO). Financial support for the printing of this thesis was kindly provided by Stichting Blindenhulp, Rotterdamse Stichting Blindenbelangen and Landelijke Stichting voor Blinden en Slechtzienden.