Small-molecule tools to study human cysteine enzymes SENPs and PARK7

Author(s):
Jia, Y.
Published
2023
Publication type
Doctoral Thesis

Abstract

The research presented here not only describes attempts to develop selective inhibitors for SENPs and PARK7 but also provides a chemical toolbox to study the function of PARK7. Both SENPs and PARK7 are attractive therapeutic targets for drug development. The results of the research and chemical tools described in this thesis will further aid in the development of more potent and selective inhibitors of SENPs and PARK7 for therapeutic purposes.

PARK7SENPssmall molecule inhibitorsactivity based probesfluorescence polarization
Defense date
2023-02-01
Language
English
Supervisor(s)
Vertegaal, A.C.O.; Ovaa, H.
Advisor(s)
Geurink, P.P.; Sapmaz, A.
Committee member(s)
Neefjes, J.J.C.; Dijke, P. ten; Aye, Y.; Stelt, M. van der; Hacker, S.M.
Qualification
Ph.D.
Degree granting institution
Faculty of Medicine, Leiden University Medical Center (LUMC), Leiden University, Leiden
hdl
1887/3514281
ISBN(s)
9789493289192