Sequence-based identification of metronidazole-resistant Clostridioides difficile isolates

Author(s):
Smits, W.K. (0000-0002-7409-2847); Harmanus, C.; Sanders, I.M.J.G.; Bry, L.; Blackwell, G.A.; Ducarmon, Q.R.; Ferreira, E.D.; Kuijper, E.J.
Published
2022
Publication type
Article / Letter to editor

Abstract

The plasmid pCD-METRO confers metronidazole re-sistance in Clostridioides difficile. We showed high se-quence similarity among pCD-METRO plasmids from different isolates and identified pCD-METRO and as-sociated metronidazole-resistant isolates in clinical and veterinary reservoirs in the Americas. We recommend using PCR or genomic assays to detect pCD-METRO in metronidazole-resistant C. difficile.

Date issued
2022-11-01
Language
English
Publisher
CENTERS DISEASE CONTROL & PREVENTION
Is part of
Emerging Infectious Diseases (2022), Vol. 28, no. 11, p. 2308-2311
hdl
1887/3505725
doi
10.3201/eid2811.220615
URL
https://wwwnc.cdc.gov/eid/article/28/11/22-0615_article