The effect of immunosuppression or thymectomy on the response to tetanus revaccination in myasthenia gravis

Author(s):
Strijbos, E.; Dam, M.M.V.T.; Vervat, C.; Schilham, M.W. (0000-0003-4391-6003); Huijbers, M.G.M. (0000-0002-6082-5042); Tol, M.J.D. van (0000-0003-1600-4279); Verschuuren, J.J.G.M. (0000-0002-4572-1501)
Published
2022
Publication type
Article / Letter to editor

Abstract

Objective: To determine the effect of tetanus toxoid (TT) revaccination on circulating B-, T-and NK-cell com-partments in myasthenia gravis (MG) patients.Methods: Lymphocyte (sub)populations and differentiation stages were assessed by flow cytometry in 50 TT revaccinated MG patients. TT-specific proliferative responses were explored in PBMC cultures. Results: In patients treated with azathioprine B-and NK cell numbers were strongly decreased. Lymphocyte (sub) populations remained unaffected upon TT revaccination. t All patients showed a significant TT-induced prolif-erative response.Conclusion: TT revaccination is effective in MG patients with stable disease irrespective of their thymectomy status and medication and does not alter the composition of the lymphocyte compartment.

VaccinationAutoimmunityMyasthenia gravisT lymphocyteB lymphocyteNK cellsImmunosuppressionThymectomy
Date issued
2022-09-15
Language
English
Publisher
ELSEVIER
Is part of
Journal of Neuroimmunology
hdl
1887/3502225
doi
10.1016/j.jneuroim.2022.577930
URL
https://www.jni-journal.com/article/S0165-5728(22)00125-4/fulltext