mRNA and drug delivery with lipid-based nanoparticles

Zeng, Y. (2022)

Doctoral Thesis

This thesis focuses on the application of lipid-based nanomedicine in drug delivery, including small molecular antitumor drugs and biomacromolecules including mRNA, and evaluates their biological performance. We have modified liposomes and LNPs with fusogenic coiled-coil peptides to enhance the drug/mRNA delivery efficiency (Chapter 2-4), and also investigated how the lipid composition of LNPs influences the immune response (Chapter 5).

• mRNA
• Membrane fusion
• Lipid-nanoparticles
• Coiled-coil peptides
• Non-viral

• All authors: Zeng, Y.
• Supervisor: kros, A.
• Co-supervisor: Boyle, A.L.
• Committee: Ubbink, M.; Dame, R.T.; Jonkheijm, P.; Kieltyka, R.E.; Vader, P.
• Qualification: Doctor (dr.)
• Awarding Institution: Leiden Institute of Chemistry (LIC), Faculty of Science, Leiden University
• Date: 2022-12-06