mRNA and drug delivery with lipid-based nanoparticles

Author(s):
Zeng, Y.
Published
2022
Publication type
Doctoral Thesis

Abstract

This thesis focuses on the application of lipid-based nanomedicine in drug delivery, including small molecular antitumor drugs and biomacromolecules including mRNA, and evaluates their biological performance. We have modified liposomes and LNPs with fusogenic coiled-coil peptides to enhance the drug/mRNA delivery efficiency (Chapter 2-4), and also investigated how the lipid composition of LNPs influences the immune response (Chapter 5).

mRNAMembrane fusionLipid-nanoparticlesCoiled-coil peptidesNon-viral
Defense date
2022-12-06
Language
English
Supervisor(s)
kros, A.
Advisor(s)
Boyle, A.L.
Committee member(s)
Ubbink, M.; Dame, R.T.; Jonkheijm, P.; Kieltyka, R.E.; Vader, P.
Qualification
Ph.D.
Degree granting institution
Leiden Institute of Chemistry (LIC), Faculty of Science, Leiden University, Leiden
hdl
1887/3492640