Differences Between Asymmetric cis and trans Platinum Complexes. Applications in Cancer Chemotherapy

Abstract

This thesis describes a variety of asymmetric cis- and trans-platinum(II) complexes. The major aim of this research has been the design of complexes with high antitumor activity that may overcome cisplatin resistance, and to establish a comparison between complexes with both geometries. These new type of asymmetric platinum complexes contain in all cases the iPram ligand and in addition either aliphatic amines or azole ligands. Furthermore, a strong emphasis on asymmetric trans-Pt(II) complexes with azole ligands is presented in this research.