Immune modulation and monitoring of cell therapy in inflammatory disorders

Author(s):
Suwandi, J.S.
Published
2022
Publication type
Doctoral Thesis

Abstract

The immune system consists of a complex network that protects the body from pathogens and cancer. Autoimmune diseases and inflammatory conditions are caused by a disturbed and unbalanced immune system in which the body's own cells are destroyed by immune cells as a result of an inflammatory reaction. In this thesis, I focused on type 1 diabetes as an autoimmune disease to investigate the derailment of the immune system and explored strategies involving cell therapy with tolerogenic

dendritic cells to restore immune tolerance. In addition, I studied the application of cell therapy in other inflammatory disorders such as rheumatoid arthritis and graft-versus-host disease.

Immune modulationCell therapyTolerogenic dendritic cellsMesenchymal stromal cells Immune monitoringRegulatory T-cellsMass cytometry
Defense date
2022-10-18
Language
English
Supervisor(s)
Roep, B.O.; Zwaginga, J.J.
Advisor(s)
Nikolic, T.
Committee member(s)
Lankester, A.C.; Staal, F.J.T.; Koning, E.J.P. de; Kooyk, Y. van; Rodriguez-Calvo, T.
Qualification
Ph.D.
Degree granting institution
Faculty of Medicine, Leiden University Medical Center (LUMC), Leiden University, Leiden
hdl
1887/3480350
ISBN(s)
9789464238976