Cytokine-mediated regulation of immunity during persistent viral infection

Author(s):
Pratumchai, I.
Published
2022
Publication type
Doctoral Thesis

Abstract

T cell exhaustion is a state of T cell hypofunction arising during persistent viral infections and cancer. Recent advances in the field of immunology uncover the roles of cytokines in regulating T cell responses. Using LCMV Clone-13 as a model of persistent viral infection, this thesis investigates the roles of IL-27 and IFN-I in regulating T cells during infection. In addition, the thesis explores the potential of JAK inhibitor in rescuing T cell exhaustion during persistent viral infection and cancer.

IL-27T cell exhaustionImmunotherapyCD8 T cellsCytokinesCancerPersistent viral infectionChronic viral infectionInterferonLCMV
Defense date
2022-09-20
Language
English
Supervisor(s)
Neefjes, J.J.C.
Advisor(s)
Arens, R.; Teijaro, J.R.
Committee member(s)
Borst, J.G.; Schumacher, A.N.M.; Ham, S.M. van; Mebius, R.E.; Veen, A.G. van der
Qualification
Ph.D.
Degree granting institution
Faculty of Medicine, Leiden University Medical Center (LUMC), Leiden University, Leiden
hdl
1887/3459110

Funding

Sponsorship
R01AI118862; R01AI123210