The tumor-stroma ratio in epithelial cancer types: towards implementation in diagnostic pathology

Author(s):
Smit, M.A.
Published
2022
Publication type
Doctoral Thesis

Abstract

This thesis describes the steps necessary for the addition of the tumor-stroma ratio (TSR) into clinical practice as high-risk factor besides the TNM classification. The route from laboratory biomarker development to clinical implementation is followed. During this process, the relationship of the TSR to other available biomarkers for prognostic information for breast and colon cancer patients is investigated. Additionally, the prognostic value of the TSR in lung cancer is studied.

Tumor-stroma ratioColon cancerPersonalized MedicinePrognostic parameterBreast cancerSquamous cell lung cancerDeep learningArticificial intelligence
Defense date
2022-06-30
Language
English
Supervisor(s)
Tollenaar, R.A.E.M.; Krieken, J.H.J.M. van
Advisor(s)
Mesker, W.E.
Committee member(s)
Hardwick, J.C.H.; Grünberg, K.; Tanis, P.J.; Peeters, K.C.M.J.
Qualification
Ph.D.
Degree granting institution
Faculty of Medicine, Leiden University Medical Center (LUMC), Leiden University, Leiden
hdl
1887/3421285
ISBN(s)
9789464238259