Core cross-linked polymeric micelles based on polypept(o)ides: from secondary structure formation of polypeptides to functional cross-linking strategies for polymeric micelles

Abstract

This thesis aimed to investigate core cross-linked polymeric micelles (CCPMs) and expand their potential for the delivery of hydrophobic drugs and co-factors. Applying polypept(o)ides as the polymeric platform technology, the fundamental implications of secondary structure formation on ring-opening N-carboxyanhydride (NCA) polymerization and self-assembly were examined and optimized. CCPMs with functional core architectures serving external or disease-related stimuli were developed. To establish robust CCPM production, overcome drug resistance mechanisms, and explore therapeutic agents for immunomodulation, polymer science was combined with organic and inorganic chemistry.