Effectiveness and toxicity of radiotherapy treatment for painful spinal metastases: a detailed course of side effects after opposing fields versus a single posterior field technique.

Author(s):
Westhoff, P.G.; Graeff, A. de; Monninkhof, E.M.; Pree, I. de; Vulpen, M. van; Leer, J.W.H.; Marijnen, C.A.M. (0000-0003-0189-5953); Linden, Y.M. van der (0000-0002-9003-6124); Dutch Bone Metastasis Study Grp
Published
2018
Publication type
Article / Letter to editor

Abstract

Background Conventional radiotherapy for painful spinal metastases can be delivered with a single posterior-anterior (PA) or two opposed anterior-posterior (APPA) fields. We studied the effectiveness and toxicity of both techniques and studied whether treatment technique was predictive for abdominal and skin toxicity. Patients and methods Within the Dutch Bone Metastasis Study, 343 patients received 8 Gray in a single fraction or 24 Gray in six fractions for painful spinal metastases. Treatment technique was not randomized. At baseline and weekly during follow-up, patients reported pain and other physical complaints. Any complaint increasing within 4 weeks after treatment was noted as a side effect. Pain response was calculated according to international standards, taking into account changes in pain score and medication. Repeated measurement analyses and multivariate logistic analyses were performed

Date issued
2018-03-01
Language
English
Is part of
journal of radiation oncology (2018), Vol. 7, no. 1, p. 17-26
hdl
1887/3280447
doi
10.1007/s13566-017-0328-1