Salvage surgery for residual or recurrent laryngeal squamous cell carcinoma after (Chemo)radiotherapy: Oncological outcomes and prognostic factors

Author(s):
Vander Poorten, V.; Meulemans, J.; Beitler, J.J.; Piazza, C.; Kowalski, L.P.; Makitie, A.A.; Paleri, V.; Rinaldo, A.; Robbins, K.T.; Rodrigo, J.P.; Silver, C.E.; Sjogren, E.V.; Strojan, P.; Takes, R.P.; Ferlito, A.
Published
2021
Publication type
Article / Letter to editor

Abstract

Nonsurgical primary treatment of early and advanced laryngeal squamous cell carcinoma, employing radiotherapy with or without chemotherapy, is considered a standard of care in many centers throughout the world. When patients have persistent or recurrent disease after non-surgical treatment, salvage surgery is frequently the only remaining potentially curative treatment. Depending on the extent of the residual/recurrent disease, different surgical salvage options are at the surgeon's disposal. In selected cases with limited local disease, salvage transoral laser microsurgery, transoral robotic surgery and open partial laryngectomies can be employed to achieve cure while preserving laryngeal function. For more advanced cases total laryngectomy is necessary. Identifying situations with unacceptable results from surgical salvage may guide future therapies. (C) 2021 Elsevier Ltd, BASO similar to The Association for Cancer Surgery, and the European Society of Surgical Oncology. All rights reserved.

Conservation surgeryLaryngeal carcinomaOncological outcomesPrognostic factorsSalvage surgeryTotal laryngectomyTransoral laser microsurgerySquamous cell carcinoma
Date issued
2021-11-01
Language
English
Publisher
ELSEVIER SCI LTD
Is part of
EJSO - European Journal of Surgical Oncology (2021), Vol. 47, no. 11, p. 2711-2721
hdl
1887/3279827
doi
10.1016/j.ejso.2021.05.035