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Lopci, E.; Kobe, C.; Gnanasegaran, G.; Adam, J.A.; Geus-Oei, L.F. de (2021)

PET/CT Variants and Pitfalls in Lung Cancer and Mesothelioma

Article / Letter to editor
2-deoxy-2-[F-18]fluoro-D-glucose [F-18]FDG-PET/CT represents the metabolic imaging of choice in various cancer types. Used either at diagnosis or during treatment response assessment, the modality allows for a more accurate definition of tumor extent compared to morphological imaging and is able to predict the therapeutic benefit earlier in time. Due to the aspecific uptake property of [F-18]FDG there is an overlap of its distribution in normal and pathological conditions, which can make the interpretation of the imaging challenging. Lung and pleural neoplasia are no exception to this, thus acknowledging of possible pitfalls and artifacts are mandatory for image interpretation. While most pitfalls and artifacts are common for all indications with metabolic imaging with [F-18]FDG-PET/CT, there are specific variants and pitfalls in lung cancer and malignant pleural mesothelioma. The aim of the present article is to shed light on the most frequent and relevant variants and pitfalls in ...Show more2-deoxy-2-[F-18]fluoro-D-glucose [F-18]FDG-PET/CT represents the metabolic imaging of choice in various cancer types. Used either at diagnosis or during treatment response assessment, the modality allows for a more accurate definition of tumor extent compared to morphological imaging and is able to predict the therapeutic benefit earlier in time. Due to the aspecific uptake property of [F-18]FDG there is an overlap of its distribution in normal and pathological conditions, which can make the interpretation of the imaging challenging. Lung and pleural neoplasia are no exception to this, thus acknowledging of possible pitfalls and artifacts are mandatory for image interpretation. While most pitfalls and artifacts are common for all indications with metabolic imaging with [F-18]FDG-PET/CT, there are specific variants and pitfalls in lung cancer and malignant pleural mesothelioma. The aim of the present article is to shed light on the most frequent and relevant variants and pitfalls in [F-18] FDG-PET/CT imaging in lung cancer and malignant pleural mesothelioma. (C) 2021 Elsevier Inc. All rights reserved.Show less
All authors
Lopci, E.; Kobe, C.; Gnanasegaran, G.; Adam, J.A.; Geus-Oei, L.F. de
Date
2021-09-01
Journal
Seminars in Nuclear Medicine
Volume
51
Issue
5
Pages
458 - 473
DOI
doi:10.1053/j.semnuclmed.2021.04.002