Liposomes as delivery system for allergen-specific immunotherapy

Author(s):
Leboux, R.J.T.
Published
2021
Publication type
Doctoral Thesis

Abstract

In this book liposomes are explored as delivery system for allergen-specific immunotherapy. Both cationic and anionic formulations are prepared with Bet v 1, one of the allergens in birch pollen.

Moreover, a novel method is described which can be used to associate antigens with liposomes. This method is based on coiled-coil forming interaction of two complementary peptides.

Allergen-specific immunotherapyBet v 1Coiled coilCationic liposomesAnionic liposomes
Defense date
2021-11-16
Language
English
Supervisor(s)
Jiskoot, W.; Kros, A.; Irth, H.
Advisor(s)
Slütter, B.A.
Committee member(s)
Bouwstra, J.; Foged, C.; Kersten, G.F.A.; Kasteren, S.I. van; Mastrobattista, E.; Perrie, Y.
Qualification
Ph.D.
Degree granting institution
Leiden Academic Centre for Drug Research (LACDR), Faculty of Science, Leiden University, Leiden
hdl
1887/3240101
ISBN(s)
9789464215465