The autoimmune hypothesis of narcolepsy and its unexplored clinical features
Abstract
The mechanisms involved in the autoimmune hypothesis of narcolepsy are investigated in this thesis. The role of HLA, auto- and cross-reactive T cells is explored and immune cell populations of interest are identified by a new technique, called mass cytometry. The second part of the thesis assesses unexplored clinical features of narcolepsy, such as weight gain and sleep state misperception.
NarcolepsyHypersomniaAutoimmuneMass cytometryT cellsSleep disordersSleep state misperceptionNeurology
