The autoimmune hypothesis of narcolepsy and its unexplored clinical features

Schinkelshoek, M.S. (2021)

Doctoral Thesis

The mechanisms involved in the autoimmune hypothesis of narcolepsy are investigated in this thesis. The role of HLA, auto- and cross-reactive T cells is explored and immune cell populations of interest are identified by a new technique, called mass cytometry. The second part of the thesis assesses unexplored clinical features of narcolepsy, such as weight gain and sleep state misperception.

• Narcolepsy
• Hypersomnia
• Autoimmune
• Mass cytometry
• T cells
• Sleep disorders
• Sleep state misperception
• Neurology

• All authors: Schinkelshoek, M.S.
• Supervisor: Lammers, G.J.; Koning, F.
• Co-supervisor: Fronczek, R.
• Committee: Verschuuren, J.J.G.M.; Overeem, S.; Kornum, B.R.
• Qualification: Doctor (dr.)
• Awarding Institution: Faculty of Medicine, Leiden University Medical Center (LUMC), Leiden University
• Date: 2021-11-11
• ISBN (print): 9789463327961
• Sponsorship: Bioprojet (kosten drukken proefschrift); SEIN (Stichting Epilepsie Instellingen Nederland); NSWO; SVNL