Circadian control of brown adipose tissue

Author(s):
Straat, M.E.; Hogenboom, R.; Boon, M.R.; Rensen, P.C.N. (0000-0002-8455-4988); Kooijman, S. (0000-0002-0014-5571)
Published
2021
Publication type
Article / Letter to editor

Abstract

Disruption of circadian (similar to 24 h) rhythms is associated with an increased risk of cardiometabolic diseases. Therefore, unravelling how circadian rhythms are regulated in different metabolic tissues has become a prominent research focus. Of particular interest is brown adipose tissue (BAT), which combusts triglyceride-derived fatty acids and glucose into heat and displays a circannual and diurnal rhythm in its thermogenic activity. In this review, the genetic, neuronal and endocrine generation of these rhythms in BAT is discussed. In addition, the potential risks of disruption or attenuation of these rhythms in BAT, and possible factors influencing these rhythms, are addressed.

Brown adipocytesCardiometabolic healthCircadian rhythmLipidsShift work
Date issued
2021-08-01
Language
English
Publisher
ELSEVIER
Is part of
Biochimica et Biophysica Acta - Molecular and Cell Biology of Lipids (2021), No. 8
hdl
1887/3235971
doi
10.1016/j.bbalip.2021.158961
URL
https://www.sciencedirect.com/science/article/pii/S1388198121000895?via%3Dihub