IL11: A Specific Repressor of Tumor-Specific CD4(+) T Cells

Author(s):
Burg, S.H. van der (0000-0002-6556-0354)
Published
2021
Publication type
Article / Letter to editor

Abstract

CD4(+) T helper 1 (Th1) cells have a key role in tumor immunity by producing effector cytokines that orchestrate the tumoricidal effects of cytotoxic T lymphocytes, natural killer cells, and macrophages and directly exert tumor growth control via the induction of tumor cell senescence and inhibition of angiogenesis. In this issue, Huynh and colleagues report a new role for IL11 in fostering tumor outgrowth by suppressing the effector mechanisms of intratumoral CD4(+) Th1 cells.

Date issued
2021-07-01
Language
English
Publisher
AMER ASSOC CANCER RESEARCH
Is part of
Cancer Immunology Research (2021), Vol. 9, no. 7, p. 724-724
hdl
1887/3209073
doi
10.1158/2326-6066.CIR-21-0248