Interactions between oxytocin receptor gene methylation and callous-unemotional traits impact socioaffective brain systems in conduct-disordered offenders.

Author(s):
Aghajani, M.; Klapwijk, E.T. (0000-0002-8936-0365); Colins, O.F.; Ziegler, C.; Domschke, K.; Vermeiren, R.R.J.M.; Van der Wee, N.J.A.
Published
2018
Publication type
Article / Letter to editor

Abstract

interacts with CU traits to impact socioaffective brain systems in youngsters with CD.

× CU trait interactions on corticolimbic activity and amygdala subregional connections during recognition and resonance of distressing socioaffective stimuli (angry and fearful faces), in juvenile offenders with CD (n = 39) versus matched healthy control youths (n = 27).

and CU levels in youths with CD additionally predicted centromedial amygdala decoupling from ventromedial/orbitofrontal regions during emotion recognition, along with basolateral amygdala decoupling from precuneal and temporoparietal cortices during emotion resonance.

and CU traits in youths with CD may affect brain systems critical to decoding and integrating socioaffective information. Developmental models of CU traits and psychopathy could thus possibly advance by further examining OXTR epigenetic effects, which may hold promise for indicated prevention and personalized treatment by targeting oxytocinergic function. BACKGROUND METHODS RESULTS CONCLUSIONS

Date issued
2018-05-01
Language
English
Is part of
hdl
1887/3203189
doi
10.1016/j.bpsc.2017.12.010
URL
https://www.sciencedirect.com/science/article/pii/S2451902218300028?via=ihub