Exposure to acetaminophen and all its metabolites upon 10, 15, and 20 mg/kg intravenous acetaminophen in very-preterm infants

Author(s):
Flint, R.B.; Roofthooft, D.W.; Rongen, A. van; Lingen, R.A.; Anker, J.N. van den; Dijk, M. van; Allegaert, K.; Tibboel, D.; Knibbe, C.A.J. (0000-0001-9893-4415); Simons, S.H.P.
Published
2017
Publication type
Article / Letter to editor

Abstract

) was related to dose and gestational age.ResultsBetween 10 and 20 mg/kg dose, median AUCs of acetaminophen, glucuronide, sulfate, and cysteine increased significantly resulting in unchanged ratios of AUC of metabolite to acetaminophen. The AUC ratio of glucuronide to acetaminophen increased with gestational age, that of sulfate decreased, and the ratio of cysteine and mercapturate remained unchanged.ConclusionWe found a gestational-age-dependent increase in glucuronidation but no evidence for saturation of a specific pathway as there was a proportional increase in exposure of acetaminophen and all metabolites. Compared with adults, very low exposure to glucuronide but higher exposure to sulfate, cysteine, and mercapturate metabolites was found, of which the relevance is not yet known.

Date issued
2017-10-30
Language
English
Is part of
hdl
1887/3202687
doi
10.1038/pr.2017.129