Silencing anticoagulant protein c causes spontaneous atherothrombosis in ApoE knockout mice

Author(s):
Ouweneel, A.B. (0000-0002-3476-264X); Heestermans, M.; Verwilligen, R.A.F.; Eck, M. van (0000-0003-3936-3194); Vlijmen, B.J.M. van
Published
2016
Publication type
Article / Letter to editor

Abstract

Objectives: Studies on atherothrombosis, a major cause of cardiovascular

events, are hampered by the lack of animal models spontaneously developing

atherothrombosis. Major underlying problems are the stability of the atherosclerotic plaques, combined with the strong plasma anticoagulant activity. We hypothesized that inhibition of the anticoagulant system by silencing of protein C (Proc) may cause murine atherosclerotic plaques to become prone to atherothrombosis.

Date issued
2016-09-30
Language
English
Is part of
hdl
1887/3201774
doi
10.1016/j.atherosclerosis.2016.07.318