Metal-ion nucleic-acid interactions: A personal account

Author(s):
Reedijk, J. (0000-0002-6739-8514)
Published
2016
Publication type
Article / Letter to editor

Abstract

A brief personal account is given on how I observed and enjoyed studying metal-ion nucleic-acid binding over the last 40 years, based on contributions from my own group and from our collaborators and competitors.Metal ions do bind to ligands, and the nucleic acids not only can act as metal-binding ligands, but also as hydrogen-bonding species, as typically known for Watson-Crick base pairs. In the study of metal nucleic acid binding, coordination and hydrogen bonding do often occur together and may act synergistically. In this account I will highlight a selection of our most important findings within the context of this special issue. (C) 2015 Elsevier B.V. All rights reserved.

Date issued
2016-10-01
Language
English
Publisher
ELSEVIER SCIENCE SA
Is part of
hdl
1887/3201138
doi
10.1016/j.ica.2015.12.011