Barrier Capability of Skin Lipid Models: Effect of Ceramides and Free Fatty Acid Composition

Author(s):
Uche, L.E.; Gooris, G.S.; Bouwstra, J.A. (0000-0002-7123-6868); Beddoes, C.M. (0000-0001-7449-1031)
Published
2019
Publication type
Article / Letter to editor

Abstract

-aminobenzoate permeation and transepidermal water loss values as markers for barrier function, we determined that the alterations in SC lipid composition contribute to the impaired barrier function in AD patients. By the use of biophysical techniques, we established that the largest reduction in barrier capability was observed in the model with an increased fraction of short-chain FFAs, evident by the decrease in chain packing density. Modulations in the CER subclass composition impacted the lamellar organization while having a smaller effect on the barrier function. These findings provide evidence that AD therapies normalizing the FFA composition are at least as important as normalizing CER composition.

Date issued
2019-11-26
Language
English
Is part of
Langmuir (2019), Vol. 35, no. 47, p. 15376-15388
hdl
1887/3199136
doi
10.1021/acs.langmuir.9b03029