Synthesis of cyclic peptides as bioconjugation platforms

Author(s):
Peterse, E.
Published
2021
Publication type
Doctoral Thesis

Abstract

Cyclic peptides are investigated as a platform to induce different orientations between various ligands. Through click chemistry, a variety of Toll-like receptor ligands can be attached to the cyclic peptides, which are based on gramicidin S.

Gramicidin SClick ChemistryToll-like receptor ligandsCyclic PeptideOn-resin cyclization
Defense date
2021-06-29
Language
English
Supervisor(s)
Overkleeft, H.S.
Advisor(s)
Filippov, D.V.
Committee member(s)
Marel, G.A. van der; Stelt, M. van der; Ossendorp, F.A.; Maarseveen, J. van; Kasteren, S.I. van; Boyle, A.L.
Qualification
Ph.D.
Degree granting institution
Leiden Institute of Chemistry (LIC), Faculty of Science, Leiden University, Leiden
hdl
1887/3192731
ISBN(s)
9789463327596