Disruption of PLTP (phospholipid transfer protein)-mediated HDL (high-density lipoprotein) maturation reduces SR-BI (scavenger receptor BI) deficiency-driven atherosclerosis susceptibility despite unexpected metabolic complications

Author(s):
Hoekstra, M. (0000-0001-7463-2893); Sluis, R.J. van der (0000-0002-3435-8356); Hildebrand, R.B.; Lammers, B.; Zhao, Y.; Praticò, D.; Berkel, T.J.C. van; Rensen, P.C.N.; Kooijman, S.; Jauhiainen, M.; Eck, M. van (0000-0003-3936-3194)
Published
2020
Publication type
Article / Letter to editor

Abstract

C]cholesteryl oleate after intravenous VLDL-like particle injection.

We have shown that disruption of PLTP-mediated HDL maturation reduces SR-BI deficiency-driven atherosclerosis susceptibility in mice despite the induction of proatherogenic metabolic complications in the double knockout mice.

OBJECTIVE

CONCLUSIONS

AtherosclerosisDiet, high fatHypertriglyceridemiaMiceObesity
Date issued
2020-01-16
Language
English
Is part of
Arteriosclerosis, Thrombosis, and Vascular Biology (2020), Vol. 40, no. 3, p. 611-623
hdl
1887/3188385
doi
10.1161/ATVBAHA.119.313862