Vitamin K therapy to reduce bleeding

Abstract

In this issue of Blood, Chen et al(1) used a cell-based screening to identify 9 unrelated drugs that may cause bleeding by interfering with the vitamin K (VK) cycle that is required for the VK-dependent g-carboxylation of blood coagulation proteins. Bleeding caused by drugs inhibiting the reduction of VK epoxide, but not VK, can be rescued by VK administration.