Update 2020: nomenclature and listing of celiac disease-relevant gluten epitopes recognized by CD4(+) T cells

Author(s):
Sollid, L.M.; Tye-Din, J.A.; Qiao, S.W.; Anderson, R.P.; Gianfrani, C.; Koning, F. (0000-0002-4007-5715)
Published
2020
Publication type
Article / Letter to editor

Abstract

Celiac disease is caused by an abnormal intestinal T cell response to cereal gluten proteins. The disease has a strong human leukocyte antigen (HLA) association, and CD4(+) T cells recognizing gluten epitopes presented by disease-associated HLA-DQ allotypes are considered to be drivers of the disease. This paper provides an update of the currently known HLA-DQ restricted gluten T cell epitopes with their names and sequences.

Celiac diseaseGlutenT cellEpitopesHLA-DQ2HLA-DQ8
Date issued
2020-02-01
Language
English
Publisher
SPRINGER
Is part of
Immunogenetics (2020), Vol. 72, no. 1-2, p. 85-88
hdl
1887/3184061
doi
10.1007/s00251-019-01141-w
URL
https://link.springer.com/article/10.1007/s00251-019-01141-w