BETting on stem cell expansion

Author(s):
Staal, F.J.T. (0000-0003-1588-8519); Fibbe, W.E. (0000-0001-8539-9011)
Published
2020
Publication type
Other

Abstract

For decades, the expansion of hematopoietic stem cells (HSCs) has been an elusive goal. In this issue of Blood, Hua et al took a step toward reaching this goal by demonstrating that the addition of the small molecule bromodomain and extra-terminal motif (BET) inhibitor CPI203 to a cytokine cocktail results in expansion of serially transplantable long-term repopulating HSCs (LT-HSCs). They also showed enhancement of their potential to differentiate into megakaryocytes (MKs).(1)

Date issued
2020-11-19
Language
English
Publisher
AMER SOC HEMATOLOGY
hdl
1887/3184042
doi
10.1182/blood.2020007759
URL
https://ashpublications.org/blood/article/136/21/2364/474153/BETting-on-stem-cell-expansion