HLA associations in narcolepsy type 1 persist after the 2009 H1N1 pandemic

Author(s):
Schinkelshoek, M.; Fronczek, R.; Verduijn, W.; Haasnoot, G.; Overeem, S.; Donjacour, C.; Heide, A. van der; Roelen, D.; Claas, F.; Lammers, G.J.
Published
2020
Publication type
Article / Letter to editor

Abstract

We aimed to compare HLA-DQB1-associations in narcolepsy type 1 (NT1) patients with disease onset before and after the 2009 H1N1 pandemic in a large Dutch cohort 525 NT1 patients and 1272 HLA-DQB1*06:02-positive healthy controls were included. Because of the discussion that has arisen on the existence of sporadic and post-H1N1 NT1, HLA-DQB1-associations in pre- and post-H1N1 NT1 patients were compared. The associations between HLA-DQB1 alleles and NT1 were not significantly different between pre- and post-H1N1 NT1 patients. Both HLA-DQB1-associations with pre- and -post H1N1 NT1 reported in recent smaller studies were replicated. Our findings combine the results of studies in pre- and post-H1N1 NT1 and argue against considering post-H1N1 NT1 as a different entity.

NarcolepsyH1N1HLAHypocretinAuto-immune disease
Date issued
2020-05-15
Language
English
Publisher
ELSEVIER
Is part of
Journal of Neuroimmunology
hdl
1887/3182665
doi
10.1016/j.jneuroim.2020.577210
URL
https://www.sciencedirect.com/science/article/pii/S0165572819306186?via%3Dihub