Conventional autoantibodies against brain antigens are not routinely detectable in serum and CSF of narcolepsy type 1 and 2 patients

Author(s):
Dietmann, A.; Horn, M.P.; Schinkelshoek, M.S.; Fronczek, R.; Salmen, A.; Bargiotas, P.; Lammers, G.J.; Khatami, R.; Bassetti, C.L.A.
Published
2020
Publication type
Article / Letter to editor

Abstract

Narcolepsy with cataplexy (NT1) is a chronic hypothalamic disorder with a presumed immune-mediated etiology leading to a loss of hypocretin neurons. Previous studies reported conflicting results in terms of presence of auto-antibodies involved in narcolepsy pathophysiology. A total of 86 patients with primary/ idiopathic narcolepsy (74 NT1, 12 NT2) and 23 control patients with excessive daytime sleepiness due to other causes were tested for the presence of a wide range of anti-neuronal antibodies in both serum and cerebrospinal fluid (CSF). Anti-neuronal antibodies were rarely found in patients with narcolepsy (n = 2) and in controls (n = 1). Our results are in line with previous reports. We can therefore support the current evidence, that conventional anti-neuronal antibodies are not routinely detected during the workup of NT1 and other CDH patients. (c) 2020 Elsevier B.V. All rights reserved.

Narcolepsy type INarcolepsy cataplexyNarcolepsy borderlandAnti-neuronal antibodiesAutoantibodies
Date issued
2020-11-01
Language
English
Publisher
ELSEVIER
Is part of
Sleep Medicine (2020), Vol. 75, p. 188-191
hdl
1887/3182663
doi
10.1016/j.sleep.2020.08.001